Anne-Sophie meets Yuzuru Suoh in Paris while he's on a business trip. The two fall in love and she becomes his mistress. When Tamaki is born, she is forbidden by Yuzuru's mother, Shizue Suoh, to return to Japan with Yuzuru. She remains in France, raising René aka Tamaki, until he is fourteen. As Tamaki grows up, Anne-Sophie's health steadily declines.
When the de Grantaine family business goes into debt and is near bankruptcy, Shizue Suoh offers a deal to Anne-Sophie. In exchange for financial security and medical care until the end of her days, she is to relinquish all control and visitation of Tamaki to herself. Shizue does this because she is concerned for the Suoh legacy, Yuzuru having no other children to whom he can pass on the family and business legacies. Anne-Sophie tearfully accepts and it is said that she leaves France and goes into seclusion following Tamaki's departure. Though her location is supposedly unknown, Yuzuru knows. During the 2nd-year school excursion to France, Kyoya locates her and discovers that she is living quite healthily, thinking of her son every day. In Chapter 77 of the manga, it is revealed that Anne-Sophie suffers from Systemic lupus erythematosus.
In the Volume 18 of the manga, Umehito Nekozawa helps Tamaki get to his mother as she boards a plane. Anne-Sophie and Tamaki reunite for five minutes, just before Anne-Sophie returns to France following a visit to Japan for medical treatment at an Ootori hospital. Tamaki says that even five minutes is a good thing since it now means that he can visit his mother whenever he likes, and his father and Anne-Sophie are reunited. In one of the omake, when Tamaki goes to Ryoji to ask for Haruhi's hand in marriage, it is revealed that Anne-Sophie and Yuzuru have developed cordial relations with Haruhi's father.In the anime, Anne-Sophie is depicted as a housekeeper in the Tonnerre household where she develops an inter-generational friendship with the wealthy family's daughter, the Lady Éclair Tonnerre. She regales Éclair with stories about her sweet and beautiful son, which sparks the heiress's curiosity and eventual trip to Japan to meet Tamaki. Anne-Sophie's knowledge of the Tonnerre-Suoh engagement is unlikely; her potential reaction suggested by Shima Maezono, head housekeeper of the Suoh second mansion, who tells Kyoya in Ep 26 - This is Our Ouran Fair! that if Tamaki's mother is as wonderful as Tamaki says she is, she would not approve of Tamaki's leaving Ouran, no matter the reason.
Relationshipsmatriarch. Instead of becoming bitter about his lot in life, Tamaki never complains; instead, he goes out of his way to ensure that people around him are happy so that his mother should not have made her sacrifice in vain. Tamaki's musicianship has developed, in part, because his mother enjoyed hearing him play the piano and he did so often for her enjoyment. Tamaki resembles his mother in appearance and it may be speculated that his obsession with making women happy is a projection of his desire to make his mother happy. Volume 09 of the manga, that Yuzuru knows where Anne-Sophie is located, but keeps this information to himself in the hopes that Shizue and Tamaki might develop a decent relationship as he is being prepared to inherit the Suoh empire.
In collaboration with the Ootori Medical Group, a medical treatment for Anne-Sophie's illness is developed and Yuzuru brings her to Japan. During that visit, Yuzuru, Anne-Sophie and Tamaki are briefly reunited. Yuzuru's master plan is to restore the Grantaine business, force his mother into retirement, take over as President of Suoh Enterprises and make Tamaki his legitimate heir by marrying his one true love, Anne-Sophie.